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Chemical reagents, kits, columns, and other products used for DNA synthesis, and to subsequently run purification columns; includes genetic assembly systems.
MW 364.4 Da, Purity >95%. Cell-permeable Wnt pathway activator. Targets PR72/130 subunit of PP2A. Maintains ESC pluripotency when co-administered with Wnt3a in vitro. Active in vivo.
MW 285.39 g/mol, Purity >98%. First selective small conductance Ca²+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC₅₀ values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.
MW 402.65 g/mol. Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC₅₀ = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).